A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
作者： Yun Ju Sung , Lisa de Las Fuentes , Thomas W Winkler , Daniel I Chasman , Amy R Bentley
DOI: 10.1093/HMG/DDZ070
关键词:
摘要: Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic lifestyle factors. Cigarette smoking one such factor. Across five ancestries, we performed genome-wide gene-smoking interaction study mean arterial (MAP) pulse (PP) in 129 913 individuals stage 1 follow-up analysis 480 178 additional 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect BP traits, 37 recently reported us for systolic diastolic 38 newly identified (P < 5 × 10-8, false discovery rate < 0.05). also nine new signals near known loci. the loci, 8 showed significant status. They include CSMD1 insulin resistance spontaneously hypertensive rats. Many show biologic plausibility role regulation. SLC26A7 encodes chloride/bicarbonate exchanger expressed renal outer medullary collecting duct. AVPR1A widely expressed, including vascular smooth muscle cells, kidney, myocardium brain. FHAD1 long non-coding RNA overexpressed heart failure. TMEM51 was contractile function cardiomyocytes. CASP9 plays central cardiomyocyte apoptosis. Identified only African ancestry 30 novel Our findings highlight value multi-ancestry investigations, particularly studies factors, where genomic differences may contribute to findings.
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