IL1 beta impairs relational but not procedural rodent learning in a water maze task.

摘要: The behavioral signs of infectious illness have been well-documented. They typically include anorexia, somnolence, decreased locomotor activity, social and novel stimulus exploration, sexual behavior (Hart, 1988; Bluthe, Dantzer, Kelley, 1991; 1992). It is thought that sickness represents an organized set responses conserves metabolic energy, making it available for the febrile response Kent, & Proinflammatory cytokines secreted by activated macrophages other immunocompetent cells appear to mediate (Bluthe, Dantzer,& Crestani, Seguy, Cunningham DeSouza, 1993; Spadaro Dunn, 1990; Hardwick, Rothwell, Vannice, 1992; Masotto, Caspani, Grazia deSimone, Mengozzi, Scatturni, Sironi, Carenzi, Ghezzi, 1992).Among these cytokines, interleukin-1-beta (IL1β) a major ascending communication link between peripheral immune system central nervous (e.g., Hall, O’Grady, Menzies, Komaki, Arimura, Koves,