Donor Leukocyte Transfusions for Treatment of Recurrent Chronic Myelogenous Leukemia in Marrow Transplant Patients
作者： HJ Kolb , J Mittermuller , C Clemm , E Holler , G Ledderose
DOI: 10.1182/BLOOD.V76.12.2462.2462
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摘要: Three patients with hematologic relapse after bone marrow transplantation for chronic myelogenous leukemia were treated interferon alpha and transfusion of viable donor buffy coat. All had complete cytogenetic remission, which persisted 32 to 91 weeks treatment. In two graft-versus-host disease developed was by immunosuppression. These results are an example adoptive immunotherapy without cytoreductive chemotherapy or radiotherapy in human chimeras.
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bloodjournal.org参考文章(24)
Holler E, Ledderose G, Brehm G, Kolb Hj, Gerhartz Hh, Clemm C, Bauchinger M, Bender-Götze C, Mittermüller J, Walther U, Myeloablative conditioning for marrow transplantation in myelodysplastic syndromes and paroxysmal nocturnal haemoglobinuria. Bone Marrow Transplantation. ,vol. 4, pp. 29- 34 ,(1989)
Ion Gresser, Françoise Vignaux, Differential Effects of Interferon on the Expression of H-2K, H-2D, and Ia Antigens on Mouse Lymphocytes Journal of Immunology. ,vol. 118, pp. 721- 723 ,(1977)
Mang-So Tsoi, Rainer Storb, E. Donnall Thomas, Kenneth G. Lerner, Paul L. Weiden, Theodore C. Graham, Infusion of Donor Lymphocytes into Stable Canine Radiation Chimeras: Implications for Mechanism of Transplantation Tolerance Journal of Immunology. ,vol. 116, pp. 1212- 1219 ,(1976)
KM Sullivan, PL Weiden, R Storb, RP Witherspoon, A Fefer, L Fisher, CD Buckner, C Anasetti, FR Appelbaum, C Badger, Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia [published erratum appears in Blood 1989 Aug 15;74(3):1180] Blood. ,vol. 73, pp. 1720- 1728 ,(1989) , 10.1182/BLOOD.V73.6.1720.BLOODJOURNAL7361720
E Holler, HJ Kolb, A Moller, J Kempeni, S Liesenfeld, H Pechumer, W Lehmacher, G Ruckdeschel, B Gleixner, C Riedner, Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation [see comments] Blood. ,vol. 75, pp. 1011- 1016 ,(1990) , 10.1182/BLOOD.V75.4.1011.1011
Paul L. Weiden, Nancy Flournoy, E. Donnall Thomas, Ross Prentice, Alexander Fefer, C. Dean Buckner, Rainer Storb, Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts New England Journal of Medicine. ,vol. 300, pp. 1068- 1073 ,(1979) , 10.1056/NEJM197905103001902
Keith M. Sullivan, Rainer Storb, C. Dean Buckner, Alexander Fefer, Lloyd Fisher, Paul L. Weiden, Robert P. Witherspoon, Frederick R. Appelbaum, Meera Banaji, John Hansen, Paul Martin, Jean E. Sanders, Jack Singer, E. Donnall Thomas, Graft-versus-Host Disease as Adoptive Immunotherapy in Patients with Advanced Hematologic Neoplasms New England Journal of Medicine. ,vol. 320, pp. 828- 834 ,(1989) , 10.1056/NEJM198903303201303
A. J. Jeffreys, V. Wilson, S. L. Thein, Individual-specific 'fingerprints' of human DNA. Nature. ,vol. 316, pp. 76- 79 ,(1985) , 10.1038/316076A0
P J Voogt, E Goulmy, W F Veenhof, M Hamilton, W E Fibbe, J J Van Rood, J H Falkenburg, Cellularly defined minor histocompatibility antigens are differentially expressed on human hematopoietic progenitor cells. Journal of Experimental Medicine. ,vol. 168, pp. 2337- 2347 ,(1988) , 10.1084/JEM.168.6.2337
PJ Voogt, WE Fibbe, WAF Marijt, WFJ Veenhof, M Hamilton, FE Zwaan, R Willemze, JHF Falkenburg, E Goulmy, A Brand, JJ van Rood, Rejection of bone-marrow graft by recipient-derived cytotoxic T lymphocytes against minor histocompatibility antigens The Lancet. ,vol. 335, pp. 131- 134 ,(1990) , 10.1016/0140-6736(90)90003-N