SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration
作者： Li-Xin Chen , Xiao-Hua Liang , Lin Han , Zhi-Qiang Yan , Shi-Min Bao
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摘要: Brain metastases are a frequent and ongoing major complication of non-small cell lung cancer (NSCLC). To deepen our understanding to the underlying mechanisms by which NSCLC cells metastasize brain hence improve therapy, high throughput RNAi screening with shRNA library 153 epigenetic genes was subjected A549, line migration ability, examine effects these on wound-healing assay. The results showed that knockdown 2 (KDM5B SIRT1) dramatically specifically inhibits A549 but not affects proliferation, subsequently confirmed through transwell Furthermore, SIRT1 is found be highly expressed in metastasis tissues NSCLC, compared tissues, suggesting may play roles NSCLC. relationship between expression ability further investigated three lines result indicated tightly correlated ability. Collectively, work provides potential biomarker therapeutic target for
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