Resolving Inflammation by Targeting an Ancient Innate Immune Sensor with a Bacterial Metabolite
作者： Andrew Johnston
DOI: 10.1016/J.JID.2017.07.815
关键词:
摘要: Bacterial, fungal, and plant metabolites are promising sources of small molecules for drug discovery. Smith et al. show that tapinarof, a bacteria-derived polyphenol, is an aryl hydrocarbon receptor ligand attenuated inflammatory responses shows therapeutic potential skin diseases. This work adds to the growing literature stemming from renewed interest in discovery development novel with anti-inflammatory activity.
jidonline.org
elsevier.com参考文章(14)
Gordon M. Cragg, David J. Newman, Natural products: a continuing source of novel drug leads. Biochimica et Biophysica Acta. ,vol. 1830, pp. 3670- 3695 ,(2013) , 10.1016/J.BBAGEN.2013.02.008
R. Gniadecki, B. Bang, L.E. Bryld, L. Iversen, S. Lasthein, L. Skov, Comparison of long‐term drug survival and safety of biologic agents in patients with psoriasis vulgaris British Journal of Dermatology. ,vol. 172, pp. 244- 252 ,(2015) , 10.1111/BJD.13343
Paola Di Meglio, João H. Duarte, Helena Ahlfors, Nick D.L. Owens, Ying Li, Federica Villanova, Isabella Tosi, Keiji Hirota, Frank O. Nestle, Ulrich Mrowietz, Michael J. Gilchrist, Brigitta Stockinger, Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions. Immunity. ,vol. 40, pp. 989- 1001 ,(2014) , 10.1016/J.IMMUNI.2014.04.019
Ellen H. van den Bogaard, Judith G.M. Bergboer, Mieke Vonk-Bergers, Ivonne M.J.J. van Vlijmen-Willems, Stanleyson V. Hato, Pieter G.M. van der Valk, Jens Michael Schröder, Irma Joosten, Patrick L.J.M. Zeeuwen, Joost Schalkwijk, Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis Journal of Clinical Investigation. ,vol. 123, pp. 917- 927 ,(2013) , 10.1172/JCI65642
Jean-Marie Ramirez, Nicolò C. Brembilla, Olivier Sorg, Rachel Chicheportiche, Thomas Matthes, Jean-Michel Dayer, Jean-Hilaire Saurat, Eddy Roosnek, Carlo Chizzolini, Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. European Journal of Immunology. ,vol. 40, pp. 2450- 2459 ,(2010) , 10.1002/EJI.201040461
Marc Veldhoen, Keiji Hirota, Jillian Christensen, Anne O'Garra, Brigitta Stockinger, Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells Journal of Experimental Medicine. ,vol. 206, pp. 43- 49 ,(2009) , 10.1084/JEM.20081438
Mark E. Hahn, Lenka L. Allan, David H. Sherr, Regulation of constitutive and inducible AHR signaling: Complex interactions involving the AHR repressor Biochemical Pharmacology. ,vol. 77, pp. 485- 497 ,(2009) , 10.1016/J.BCP.2008.09.016
Pedro Moura-Alves, Kellen Faé, Erica Houthuys, Anca Dorhoi, Annika Kreuchwig, Jens Furkert, Nicola Barison, Anne Diehl, Antje Munder, Patricia Constant, Tatsiana Skrahina, Ute Guhlich-Bornhof, Marion Klemm, Anne-Britta Koehler, Silke Bandermann, Christian Goosmann, Hans-Joachim Mollenkopf, Robert Hurwitz, Volker Brinkmann, Simon Fillatreau, Mamadou Daffe, Burkhard Tümmler, Michael Kolbe, Hartmut Oschkinat, Gerd Krause, Stefan H. E. Kaufmann, AhR sensing of bacterial pigments regulates antibacterial defence Nature. ,vol. 512, pp. 387- 392 ,(2014) , 10.1038/NATURE13684
Brigitta Stockinger, Paola Di Meglio, Manolis Gialitakis, João H. Duarte, The Aryl Hydrocarbon Receptor: Multitasking in the Immune System Annual Review of Immunology. ,vol. 32, pp. 403- 432 ,(2014) , 10.1146/ANNUREV-IMMUNOL-032713-120245
Sung-Jun Park, Faiyaz Ahmad, Andrew Philp, Keith Baar, Tishan Williams, Haibin Luo, Hengming Ke, Holger Rehmann, Ronald Taussig, Alexandra L. Brown, Myung K. Kim, Michael A. Beaven, Alex B. Burgin, Vincent Manganiello, Jay H. Chung, Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases Cell. ,vol. 148, pp. 421- 433 ,(2012) , 10.1016/J.CELL.2012.01.017