Topological Regulation of Lipid Balance in Cells

摘要: Lipids are unevenly distributed within and between cell membranes, thus defining organelle identity. Such distribution relies on local metabolic branches mechanisms that move lipids. These processes regulated by feedback decipher topographical information in membranes then regulate lipid levels or flows. In the endoplasmic reticulum, major source, transcriptional regulators enzymes sense changes membrane features to modulate production. At Golgi apparatus, lipid-synthesizing, lipid-flippase, lipid-transport proteins (LTPs) collaborate control balance guarantee remodeling crucial for vesicular trafficking. Open questions exist regarding LTPs, which thought be sensors synthesis carriers transfer lipids organelles across long distances contact sites. A novel model is exchanging two different lipids, exploit one gradient distinct build a second gradient.