Evaluation of Novel Agents Which Target Neovasculature of Breast Tumors

摘要: Abstract : Biological studies examining the development of vascular tree in normal and disease states have identified numerous cytokines their receptors responsible for triggering maintaining this process (1-7). Tumor neovascularization is central not only to growth primary lesion but appears be a critical factor maintenance metastases (8-12). Clinical bladder cancer (9) demonstrated correlation between micro-vessel density metastases. In addition, breast by Fox et al. Aranda (11-12) that microvessel count tumors related presence lymph nodes micrometastases bone marrow. The cytokine endothelial factor-A (VEGF-A) its Flt-1 KDR been implicated as one mediators angiogenesis tumor (13-20). Up-regulation or over-expression VEGF-A ligand itself poor prognostic markers various clinical colon, pituitary cancers (21-23). Recently, Padro (24) suggested both may play role observed marrow during AML progression provide evidence VEGF/KDR pathway important leukemic growth.