Anti-HEV IgG Avidity Testing: Utility for Diagnosing Acute and Resolved Genotype 3 Infections.

摘要: European Association of the Study Liver (EASL) guidelines specify HEV RNA, as well anti-HEV IgG and IgM positive markers for acute infection. RNA assay sensitivity limitations may lead to false negative test results in patients with low levels viremia. Moreover, positivity is not a reliable indicator distinguishing between resolved infections given ability this antibody persist several months after Our study aims were assess avidity diagnosing infections, regardless serostatus, examine reliability when evaluating different genotype 3 (GT3) subtypes. Patient serum samples (n = 104) tested by utilizing DIA.PRO kit on DSX automated instrument. Among identified 32 infected GT3: GT3c 5), GT3e 8), 3f 17) GT3-unsubtyped 2). Avidity was 91.2% specificity 100%. For long-lasting persistence, an Index >70% observed. Thus, be utilized distinguish recently acquired GT3 infections. However, equivocal (Avidity > 40-70%), molecular testing will required confirm recent