The therapeutic potential of Physalis longifolia against various carcinomas

摘要: Abstract Our research highlights the nutraceutical potential of fruits Physalis longifolia Nutt. (Solanaceae) in antitumor therapy. Recently we reported isolation withaferin A, along with 22 other withanolides from aerial parts P. . Herein, present our biological, ethnobotanical, and phytochemical investigations on edible fruit (known as “wild tomatillo” or “long leaf groundcherry”) species. Specifically, dried extract was examined for its chemical composition biological activity. Explorative chromatography analysis indicated presence which further confirmed by subsequent HPLC analysis. The therapeutic orally administered also investigated, where gavage treatment induced a 60% volume reduction triple negative breast carcinomas (MDA-MB-468LN) an experimental mouse model. This encouraging data indicate dietary supplement, while supporting previously pharmaceutical potency semi-synthetic withalongolide derivatives promising chemotherapeutic candidates therapies.