Polyclonal antibody composition for treating allergy

作者: John S. Haurum , Kirsten Drejer , Ulrik Gregers Winther Morch

DOI:

关键词:

摘要: A pharmaceutical composition for treating allergy is described. The comprises as an active ingredient a recombinant polyclonal antibody or mixture of different monoclonal antibodies capable reacting with binding to allergen together one more pharmaceutically acceptable excipients. may be used topically solution, dispersion, powder, in the form microspheres. preferably produced by phage display technology. pairing specific immunoglobulin variable region light chain and heavy maintained from original immune response selected panning using question bulk transfer pairs into expression vector.

参考文章(17)
Mehdi Paborji, Nancy L. Pochopin, William P. Coppola, Joseph B. Bogardus, Chemical and physical stability of chimeric L6, a mouse-human monoclonal antibody Pharmaceutical Research. ,vol. 11, pp. 764- 771 ,(1994) , 10.1023/A:1018948901599
Wayne R. Gombotz, Susan C. Pankey, Duke Phan, Randy Drager, Karen Donaldson, Kris P. Antonsen, Allan S. Hoffman, Howard V. Raff, The stabilization of a human IgM monoclonal antibody with poly(vinylpyrrolidone). Pharmaceutical Research. ,vol. 11, pp. 624- 632 ,(1994) , 10.1023/A:1018903624373
Robert M. Platz, John S. Patton, Method and device for delivering aerosolized medicaments ,(1992)
Jacqueline Sharon, Polyclonal antibody libraries ,(1995)
Alan R. Brown, John A. Pickrell, Chamber for testing metered-dose propellant-driven aerosols of immunologically relevant proteins Journal of Immunological Methods. ,vol. 176, pp. 203- 212 ,(1994) , 10.1016/0022-1759(94)90314-X
Kazuo Maruyama, Tomoko Takizawa, Tsutomu Yuda, Stephen J Kennel, Leaf Huang, Motoharu Iwatsuru, Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol) s conjugated at their distal terminals to monoclonal antibodies Biochimica et Biophysica Acta (BBA) - Biomembranes. ,vol. 1234, pp. 74- 80 ,(1995) , 10.1016/0005-2736(94)00263-O
F. M. Piazza, S. A. Johnson, M. G. Ottolini, H. J. Schmidt, M. E. R. Darnell, V. G. Hemming, G. A. Prince, Immunotherapy of Respiratory Syncytial Virus Infection in Cotton Rats (Sigmodon fulviventer) Using IgG in a Small-Particle Aerosol The Journal of Infectious Diseases. ,vol. 166, pp. 1422- 1424 ,(1992) , 10.1093/INFDIS/166.6.1422
Adrian E. Smith, John D. Burr, George S. Axford, Jeffrey W. Etter, Shirley W. Lyons, Robert M. Platz, Apparatus and methods for dispersing dry powder medicaments ,(1995)