Cold Sterilization of Tissue Engineering Scaffolds with Compressed Carbon Dioxide
作者： Aidaris Jimenez , Michael A. Matthews , Jian Zhang
DOI:
关键词:
摘要: Methods for sterilizing a biocompatible hydrogel polymer are provided via treating the with supercritical CO 2 treatment composition at pressure of about 4 MPa to 30 and temperature 5° C. 75° The can be substantially pure or may further include hydrogen peroxide (e.g., in an amount 10 ppm 1,000 ppm). In certain embodiments, treated minutes 5 hours. According these methods, kill 90% more any S. aureus E. coli present polymer.
lens.org 参考文章(114)
C. L. Bell, N. A. Peppas, Biomedical membranes from hydrogels and interpolymer complexes Advances in Polymer Science. ,vol. 122, pp. 125- 175 ,(1995) , 10.1007/3540587888_15
Robert H. Fitzgerald, Infections of hip prostheses and artificial joints. Infectious Disease Clinics of North America. ,vol. 3, pp. 329- 338 ,(1989) , 10.1016/S0891-5520(20)30266-X
Marguerita Grimes, Tim McGloughlin, J T Pembroke, The effect of choice of sterilisation method on the biocompatibility and biodegradability of SIS (small intestinal submucosa). Bio-medical Materials and Engineering. ,vol. 15, pp. 65- 71 ,(2005)
Carmen Alvarez-Lorenzo, Haruyuki Hiratani, Process for production of hydrogel material enhanced in the intake of drugs and permitting sustained release of drugs ,(2002)
Henk F Kauffman, Michael Tamm, J André B Timmerman, Peter Borger, House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms Clinical and Molecular Allergy. ,vol. 4, pp. 5- 5 ,(2006) , 10.1186/1476-7961-4-5
Jian Zhang, Nishita Dalal, Michael A. Matthews, Lashanda N. Waller, Clint Saunders, Karen F. Fox, Alvin Fox, Supercritical carbon dioxide and hydrogen peroxide cause mild changes in spore structures associated with high killing rate of Bacillus anthracis. Journal of Microbiological Methods. ,vol. 70, pp. 442- 451 ,(2007) , 10.1016/J.MIMET.2007.05.019
K J Sweadner, M Forte, L L Nelsen, Filtration removal of endotoxin (pyrogens) in solution in different states of aggregation. Applied and Environmental Microbiology. ,vol. 34, pp. 382- 385 ,(1977) , 10.1128/AEM.34.4.382-385.1977
Bertil Eliasson, Per-Ake Hallberg, Method to make snow for insect control and device for making the same ,(1999)
Keyvan Behnam, Nanette Forsyth, Guobao Wei, Bone matrix compositions having nanoscale textured surfaces ,(2008)
Bertil Eliasson, Cleaning device and method ,(2003)