Some influences of fluorine in bioorganic chemistry

作者: David O’Hagan , Henry S. Rzepa

DOI: 10.1039/A604140J

关键词:

摘要: The stereochemical outcome on processing fluorinated substrate analogues by enzymes can often be controlled electronic and stereoelectronic factors associated with the fluorine atom.

参考文章(49)
P. Frey, S. Whitt, J. Tobin, A low-barrier hydrogen bond in the catalytic triad of serine proteases Science. ,vol. 264, pp. 1927- 1930 ,(1994) , 10.1126/SCIENCE.7661899
Ken C. Usher, S. James Remington, David P. Martin, Dale G. Drueckhammer, A very short hydrogen bond provides only moderate stabilization of an enzyme-inhibitor complex of citrate synthase. Biochemistry. ,vol. 33, pp. 7753- 7759 ,(1994) , 10.1021/BI00191A002
Robert E. Wolf, JudithAnn R. Hartman, John M. E. Storey, Bruce M. Foxman, Stephen R. Cooper, Crown thioether chemistry: structural and conformational studies of tetrathia-12-crown-4, pentathia-15-crown-5, and hexathia-18-crown-6. Implications for ligand design Journal of the American Chemical Society. ,vol. 109, pp. 4328- 4335 ,(1987) , 10.1021/JA00248A031
John J. Irwin, Tae-Kyu Ha, Jack D. Dunitz, Stereoelectronic Aspects of the Anomeric Effect in Fluoromethylamine Helvetica Chimica Acta. ,vol. 73, pp. 1805- 1817 ,(1990) , 10.1002/HLCA.19900730702