Covalently linked antigen-antibody conjugates

作者: Alexander Haas , Eike Hoffmann , Michael Grote , Sebastian Dziadek , Guy Georges

DOI:

关键词:

摘要: Herein is reported a conjugate comprising an antigen and antibody that specifically binds to the wherein covalent bond formed between amino acid residue in CDR2 of antibody, cysteine at position 53 (according Kabat) heavy chain uses thereof.

参考文章(373)
James D. Marks, Andrew Bradbury, Selection of human antibodies from phage display libraries. Methods of Molecular Biology. ,vol. 248, pp. 161- 176 ,(2004) , 10.1385/1-59259-666-5:161
Hennie R. Hoogenboom, Overview of antibody phage-display technology and its applications. Methods of Molecular Biology. ,vol. 178, pp. 1- 37 ,(2002) , 10.1385/1-59259-240-6:001
Johan Fransson, Juan C Almagro, Humanization of antibodies. Frontiers in Bioscience. ,vol. 13, pp. 1619- 1633 ,(2008)
H.P. Vollmers, S. Brandlein, Death by stress: natural IgM-induced apoptosis. Methods and Findings in Experimental and Clinical Pharmacology. ,vol. 27, pp. 185- 191 ,(2005) , 10.1358/MF.2005.27.3.890876
Valentino J Stella, Kenneth J Himmelstein, None, Prodrugs: A Chemical Approach to Targeted Drug Delivery Humana Press. pp. 247- 267 ,(1985) , 10.1007/978-1-4612-5186-6_14
Ed Harlow, David Lane, Using Antibodies: A Laboratory Manual ,(1998)
Harald Tschesche, Modern methods in protein chemistry Walter de Gruyter. ,(1983)