Meperidine: a critical review.

摘要: Meperidine was initially synthesized as an anticholinergic agent but soon discovered to have analgesic properties. Although meperidine's effects were demonstrated in vivo, the on biliary and renal tracts not been vivo. Studies clearly that meperidine is no more efficacious treating or tract spasm than comparative mu opioids. The initial studies demonstrating efficacy of mostly case reports double-blind, randomized, controlled trials specific populations. Subsequent failed demonstrate any advantages over comparable doses other analgesics. portrayed practice teaching having unique clinical advantages. are pronounced, and, addition, use complicated by side including serotonergic crisis normeperidine toxicity. Meperidine's poor efficacy, toxicity, multiple drug interactions resulted a movement replace with less toxic opioid