FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

作者: Thierry Conroy , Françoise Desseigne , Marc Ychou , Olivier Bouché , Rosine Guimbaud

DOI: 10.1056/NEJMOA1011923

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摘要: Background Data are lacking on the efficacy and safety of a combination chemotherapy regimen consisting of oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX) as …

参考文章(34)
Nadia Zeghari-Squalli, Esteban Cvitkovic, Eric Raymond, François Goldwasser, Cellular Pharmacology of the Combination of the DNA Topoisomerase I Inhibitor SN-38 and the Diaminocyclohexane Platinum Derivative Oxaliplatin Clinical Cancer Research. ,vol. 5, pp. 1189- 1196 ,(1999)
H A Burris, M J Moore, J Andersen, M R Green, M L Rothenberg, M R Modiano, M C Cripps, R K Portenoy, A M Storniolo, P Tarassoff, R Nelson, F A Dorr, C D Stephens, D D Von Hoff, Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. Journal of Clinical Oncology. ,vol. 15, pp. 2403- 2413 ,(1997) , 10.1200/JCO.1997.15.6.2403
D Osoba, G Rodrigues, J Myles, B Zee, J Pater, Interpreting the significance of changes in health-related quality-of-life scores. Journal of Clinical Oncology. ,vol. 16, pp. 139- 144 ,(1998) , 10.1200/JCO.1998.16.1.139
D.R.A. Mans, I. Grivicich, G.J. Peters, G. Schwartsmann, Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines. European Journal of Cancer. ,vol. 35, pp. 1851- 1861 ,(1999) , 10.1016/S0959-8049(99)00222-1
Volker Heinemann, Stefan Boeck, Axel Hinke, Roberto Labianca, Christophe Louvet, Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer BMC Cancer. ,vol. 8, pp. 82- 82 ,(2008) , 10.1186/1471-2407-8-82
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Sally Mullany, Phyllis A. Svingen, Scott H. Kaufmann, Charles Erlichman, Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity. Cancer Chemotherapy and Pharmacology. ,vol. 42, pp. 391- 399 ,(1998) , 10.1007/S002800050835
Franck Bonnetain, Laetitia Dahan, Emilie Maillard, Marc Ychou, Emmanuel Mitry, Pascal Hammel, Jean-Louis Legoux, Philippe Rougier, Laurent Bedenne, Jean-François Seitz, Time until definitive quality of life score deterioration as a means of longitudinal analysis for treatment trials in patients with metastatic pancreatic adenocarcinoma. European Journal of Cancer. ,vol. 46, pp. 2753- 2762 ,(2010) , 10.1016/J.EJCA.2010.07.023
Hideki Ueno, Takuji Okusaka, Akihiro Funakoshi, Hiroshi Ishii, Kenji Yamao, Osamu Ishikawa, Shinichi Ohkawa, Soh Saitoh, A phase II study of weekly irinotecan as first-line therapy for patients with metastatic pancreatic cancer Cancer Chemotherapy and Pharmacology. ,vol. 59, pp. 447- 454 ,(2007) , 10.1007/S00280-006-0283-9