The Contribution by Mitochondrially Induced Oxidative Damage to Aging in Drosophila Melanogaster

摘要: Strains of Drosophila melanogaster have been generated that vary in the mitochondrial genome and a common nuclear genome. Tetracycline was used to cure strains endocommensal bacteria, Wolbachia, which is transmitted maternally. Variation tetracycline responsive agent contributed substantially variation longevity production metabolic oxidants. Changes diurnal cycle activity investigated: such changes should be metabolism-related damage because role very active neurons, retinal cells muscle. The oxidant model predicts oxidants negatively correlated, deterioration behavior with age positively correlated. Only first prediction verified: rate change correlated oxidants, consistent this age-related change. However, data indicates for mitochondria determination longevity, other than by