Factors Affecting Local and Intra Hepatic Distant Recurrence After Surgery for Hcc: An Alternative Perspective on Microvascular Invasion and Satellitosis - A Western European Multicentre Study.

摘要: BACKGROUND Few studies have focused on risk factors which may predict an intrahepatic local recurrence (LR) the surgical edge rather than a distant (DR) in other liver segments after surgery for hepatocarcinoma (HCC). The purpose of this study was to assess both patterns recurrence. METHODS An international, multicentre, retrospective conducted by collecting data all consecutive patients with first diagnosis HCC who were treated between 2010 and 2017. presence macrovascular invasion exclusion criteria. RESULTS About 376 enrolled, and, among them, 62 presented LR, while 90 had DR. Baseline characteristics comparable two groups, but DR group much higher rate HCV infection (48.9% vs 29%, p 0.014) median nodule size (3.40 cm IQR 2.2-5.5 versus 3.0 cm 2.0-5.0 LR group, 0.025). A positive margin (R1, HR 4.721; 95% CI 1.83-12.17; 0.001) only independent factor MVI (HR 1.837; 1.03-3.77; 0.039) satellitosis 2.440, 1.43-3.77, predictive CONCLUSION are recurrence, configuring probable hallmark advanced systemic disease, regardless treatment. has be considered expression failure.