MicroRNA-451 in chronic myeloid leukemia: miR-451-BCR-ABL regulatory loop?
作者： Tereza Lopotová , Markéta Žáčková , Hana Klamová , Jana Moravcová
DOI: 10.1016/J.LEUKRES.2011.03.029
关键词:
摘要: Chronic myeloid leukemia (CML) is caused by constituve activity of BCR-ABL tyrosine kinase. Despite high efficiency imatinib, selective inhibitor, about 30% patients develop resistance. Novel markers and targets for therapy are thus necessary. MicroRNAs small intereference RNAs whose role in physiological malignant hematopoiesis has been shown. This study focused on miR-451 CML. Following our observation downregulation CML, we further show its relation to activity. Our data together with current literature indicate a more complex relationship
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