作者: Heidi W. Thermenos , Richard J. Juelich , Samantha R. DiChiara , Raquelle I. Mesholam-Gately , Kristen A. Woodberry
DOI: 10.1016/J.SCHRES.2016.02.023
关键词:
摘要: Abstract Background Deficits in working memory (WM) are a core feature of schizophrenia (SZ) and other psychotic disorders. We examined brain activity during WM persons at clinical high risk (CHR) for psychosis. Methods Thirty-seven CHR 34 healthy control participants underwent functional MRI (fMRI) on 3.0 T scanner while performing an N-back task. The sample included sub-sample who had no lifetime history treatment with psychotropic medications (n = 11). Data were analyzed using SPM8 (2-back > 0-back contrast). Pearson correlations between activity, symptoms, performance examined. Results total group medication-naive comparable to controls most demographic features performance, but significantly lower IQ. Relative controls, showed hyperactivity the left parahippocampus (PHP) caudate medication-exposed CHR, medication naive exhibited right dorsolateral prefrontal cortex (DLPFC). DLPFC was negatively correlated performance. PHP, strongly results did not withstand FDR-correction multiple comparisons. When all combined (regardless status), only trend-level PHP observed relative controls. Conclusions Medication-naive exhibit regions that subserve WM. These implicated studies emphasize importance status interpretation task - induced activity.