Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis.

作者: Heidi W. Thermenos , Richard J. Juelich , Samantha R. DiChiara , Raquelle I. Mesholam-Gately , Kristen A. Woodberry

DOI: 10.1016/J.SCHRES.2016.02.023

关键词:

摘要: Abstract Background Deficits in working memory (WM) are a core feature of schizophrenia (SZ) and other psychotic disorders. We examined brain activity during WM persons at clinical high risk (CHR) for psychosis. Methods Thirty-seven CHR 34 healthy control participants underwent functional MRI (fMRI) on 3.0 T scanner while performing an N-back task. The sample included sub-sample who had no lifetime history treatment with psychotropic medications (n = 11). Data were analyzed using SPM8 (2-back > 0-back contrast). Pearson correlations between activity, symptoms, performance examined. Results total group medication-naive comparable to controls most demographic features performance, but significantly lower IQ. Relative controls, showed hyperactivity the left parahippocampus (PHP) caudate medication-exposed CHR, medication naive exhibited right dorsolateral prefrontal cortex (DLPFC). DLPFC was negatively correlated performance. PHP, strongly results did not withstand FDR-correction multiple comparisons. When all combined (regardless status), only trend-level PHP observed relative controls. Conclusions Medication-naive exhibit regions that subserve WM. These implicated studies emphasize importance status interpretation task - induced activity.

参考文章(113)
Lana Kambeitz-Ilankovic, Eva M. Meisenzahl, Carlos Cabral, Sebastian von Saldern, Joseph Kambeitz, Peter Falkai, Hans-Jürgen Möller, Maximilian Reiser, Nikolaos Koutsouleris, Prediction of outcome in the psychosis prodrome using neuroanatomical pattern classification. Schizophrenia Research. ,vol. 173, pp. 159- 165 ,(2016) , 10.1016/J.SCHRES.2015.03.005
Richard C.W. Hall, Global Assessment of Functioning Psychosomatics. ,vol. 36, pp. 267- 275 ,(1995) , 10.1016/S0033-3182(95)71666-8
S Funahashi, CJ Bruce, PS Goldman-Rakic, Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic "scotomas" The Journal of Neuroscience. ,vol. 13, pp. 1479- 1497 ,(1993) , 10.1523/JNEUROSCI.13-04-01479.1993
Tandy J. Miller, Thomas H. McGlashan, Scott W. Woods, Kelly Stein, Naomi Driesen, Cheryl M. Corcoran, Ralph Hoffman, Larry Davidson, Symptom assessment in schizophrenic prodromal states. Psychiatric Quarterly. ,vol. 70, pp. 273- 287 ,(1999) , 10.1023/A:1022034115078
Ron Dumont, John O. Willis, Kathleen Veizel, Jamie Zibulsky, Wechsler Abbreviated Scale of Intelligence Encyclopedia of Special Education. ,(2014) , 10.1002/9781118660584.ESE2519
Renata Smieskova, Jonathan P. Roiser, Christopher A. Chaddock, André Schmidt, Fabienne Harrisberger, Kerstin Bendfeldt, Andor Simon, Anna Walter, Paolo Fusar-Poli, Philip K. McGuire, Undine E. Lang, Anita Riecher-Rössler, Stefan Borgwardt, Modulation of motivational salience processing during the early stages of psychosis Schizophrenia Research. ,vol. 166, pp. 17- 23 ,(2015) , 10.1016/J.SCHRES.2015.04.036
Patricia S Goldman-Rakic, E Christopher Muly III, Graham V Williams, D1 receptors in prefrontal cells and circuits Brain Research Reviews. ,vol. 31, pp. 295- 301 ,(2000) , 10.1016/S0165-0173(99)00045-4
Earl K. Miller, Cynthia A. Erickson, Robert Desimone, Neural Mechanisms of Visual Working Memory in Prefrontal Cortex of the Macaque The Journal of Neuroscience. ,vol. 16, pp. 5154- 5167 ,(1996) , 10.1523/JNEUROSCI.16-16-05154.1996
Dylan G. Gee, Tyrone D. Cannon, Prediction of conversion to psychosis: review and future directions Revista Brasileira de Psiquiatria. ,vol. 33, ,(2011) , 10.1590/S1516-44462011000600002
Katherine H. Karlsgodt, Theo G.M. van Erp, Carrie E. Bearden, Tyrone D. Cannon, Altered relationships between age and functional brain activation in adolescents at clinical high risk for psychosis. Psychiatry Research-neuroimaging. ,vol. 221, pp. 21- 29 ,(2014) , 10.1016/J.PSCYCHRESNS.2013.08.004