Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

摘要: Tumor cell migration and the concomitant degradation of extracellular matrix (ECM) are two essential steps in metastatic process. It is well established that focal adhesions (FAs) play an important role regulating migration; however, whether these structures contribute to not clear. In this study, we report multiple cancer lines display ECM at FA sites requires targeted action MT1-MMP. Importantly, have found MT1-MMP targeting dependent on association with a FAK–p130Cas complex situated FAs regulated by Src-mediated phosphorylation Tyr 573 cytoplasmic tail MT1. Disrupting FAK–p130Cas–MT1 significantly impairs FA-mediated tumor invasion yet does appear affect invadopodia formation or function. These findings demonstrate novel function for also provide molecular insights into