Effect of the type of dietary fat on biliary lipid composition and bile lithogenicity in humans with cholesterol gallstone disease.

摘要: Abstract Objective The effect of the type dietary fat on bile lipids and lithogenicity is unclear. This study compared effects two oils that differed in fatty acid profile biliary lipid composition humans. Methods Female patients who had cholesterol gallstones were scheduled for elective cholecystectomy studied. For 30 d before surgery, subjects kept diets contained olive oil (olive group, n = 9) or sunflower (sunflower as main source fat. Gallbladder stones sampled at surgery. After cholecystectomy, duodenal samples collected by nasoduodenal intubation during fasting after administration mixed liquid meals included corresponding oil. Duodenal gallbladder analyzed cholesterol, phospholipids, total acids established methods. Individual conjugates measured high-performance chromatography. Gallstones semiquantitative polarizing light microscopy. Results Despite marked differences absolute concentration content, manipulation ingestion did not influence saturation individual obtained from gallstones. All but one subject stones. A index hepatic fasted cholecystectomized was similar both groups indicative supersaturation. In response to test meal, decreased significantly given diet, reaching values lower than 120 min postprandially. contrast, secreted consumed appeared supersaturated (cholesterol >1.5) throughout experiment. Conclusions Our results suggest habitually can gallbladder, this noted presence more concentrated group. However, translated into a modification saturation, which likely due fact present time intervention started. finding typical postprandial variation occurred only revealing. While keeping mind methodologic limitations part study, some gastrointestinal metabolic mechanisms are discussed.