Obstetric cholestasis: May have serious consequences for the fetus, and needs to be taken seriously

作者: Piotr Milkiewicz , Elwyn Elias , Catherine Williamson , Judith Weaver

DOI: 10.1136/BMJ.324.7330.123

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摘要: Obstetric cholestasis (or intrahepatic of pregnancy) remains widely disregarded as an important clinical problem, with many obstetricians still considering its main symptom, pruritus, a natural association pregnancy. is associated cholesterol gallstones. It may be extremely stressful for the mother but also carries risks baby. Clinical studies clearly show that when obstetric complicates pregnancies it lead to premature births in up 60%, fetal distress 33%, and intrauterine death 2% patients.1 The cause acute anoxia.2 incidence varies from 0.1% 1.5% Europe 9.2%-15.6% South American countries such Bolivia or Chile. particularly high native Araucanian population Chile, where proportion affected reaches nearly 28%.3 low quoted reflect underestimation growing awareness condition will probably increase numbers. For example, early North America, published 1962, showed less than 0.1%, whereas study 17 years later estimated around …

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