Intravenous immunoglobulin therapy in patients with multiple mucosal involvement in mucous membrane pemphigoid.

摘要: Mucous membrane pemphigoid (MMP), also known as cicatricial (CP), is an autoimmune mucocutaneous, blistering disease which can lead to blindness and/or death from sudden asphyxiation, secondary a scarring process. Conventional therapy for the treatment of MMP consists high-dose systemic corticosteroids immunosuppressive agents. Some patients do not respond these treatments and develop multiple serious side effects, be potentially fatal. In such patients, alternative modalities are needed. This study presents use intravenous immunoglobulin (IVIg) in 15 with severe whose was nonresponsive prolonged agents who developed effects them. All received IVIg dose 1-2 g/kg/cycle. The following objective parameters were used assess clinical outcome pre- post-IVIg therapy: number frequencies recurrences relapses, duration total dosage prednisone therapy, quality life. differences variables between data statistically analyzed using SAS UNIVARIATE software running two-sided Wilcoxon signed-rank sign tests. A significant difference observed when comparing aforementioned variables. had effective response, able discontinue previous therapies, eventually achieved remission. improved life all demonstrated steroid-sparing effect. No observed. safe modality progressive induce sustained