Investigation of the prevalence of tetQ, tetX and tetX1 genes in Bacteroides strains with elevated tigecycline minimum inhibitory concentrations.

摘要: In this study, the antibiotic susceptibilities to tigecycline and tetracycline of 35 selected Bacteroides fragilis group strains were determined by Etest, presence tetQ, tetX, tetX1 ermF genes was investigated polymerase chain reaction (PCR). tetQ detected in all 12 B. isolates (100%) exhibiting elevated minimum inhibitory concentrations (MICs) (≥ 8 μg/mL) as well with a MIC 4 μg/mL, whilst tetX present 15% 75% these strains, respectively. All fully resistant (MIC ≥ 16 μg/mL). On other hand, amongst MICs μg/mL. These data suggest that most cases overcomes resistance mechanisms frequently observed strains. However, some for draws attention possible development spread agent The common occurrence ermF, together predicted CTnDOT-like conjugative transposon collection