The effect of ranitidine on postoperative infectious complications following emergency colorectal surgery: A randomized, placebo-controlled, double-blind trial

摘要: Objective and Design: To study the potential effect of ranitidine on postoperative infectious complications following emergency colorectal surgery. A randomized, placebo-controlled, double-blind trial was carried out in three university clinics two county hospitals Denmark.¶Patients Treatment: One hundred ninety-four consecutive patients undergoing acute surgery for perforated and/or obstructed large bowel were randomized a fashion to receive 100 mg i.v. twice day commencing at induction anesthesia continued five days (group I) or placebo II). All given 1.5 g metronidazole plus 3.0 cefuroxime time Patients with perforation colon rectum further 3 days. assessed daily until discharge from hospital. Thirty withdrawn (for reasons such as other diagnosis, refused continue, medication not prescribed).¶Main Outcome Measures: observed signs complications; wound infection, intra-abdominal abscess, septicemia, pneumonia.¶Results: Both groups similar respect age, sex, weight, duration surgery, blood transfusions, site procedure, well histologic nature underlying disease process. However, Mannheim Peritonitis Index (MPI) significantly higher group I compared II ( p < 0.05). Wound intraabdominal pneumonia 12.9%, 5.2%, 3.8% 14%, respectively I. In II, 16.1%, 6.8%, 6.9% 22%, respectively. Twelve (13.8%) developed more than one complication 5 (6.5%) group.¶Conclusion: Ranitidine may have beneficial