Significance of the hydrogen ion concentration in synovial fluid in rheumatoid arthritis.

摘要: The hydrogen ion (H+) concentration and pCO2 were measured in the synovial fluid (SF) from knee joints of 130 patients with arthritis by an acid-base analyser (ABL2 Acid-Base Laboratory), using a simple technique which prevented contact air. H+ was significantly higher SF 60 RA (mean 64.4 n mol/l; range 38-142 mol/l) compared OA 44 29-56 mol/l), 40 other arthritides 52 mol/l). showed significant association variables local inflammation-platelet, total leucocyte polymorph counts, 5-nucleotidase, acid phosphatase IgA levels clinical score, but not volume effusion. A similar relationship between these inflammatory activity also established. found systemically active disease, no difference pH seropositive seronegative patients. Whilst approximated to that blood OA, it lower RA. is useful marker activity, its measurement simple, reliable rapid. It relevant because changes influence many processes involved inflammation influences transfer drugs into joint.