A review of evidence linking disrupted neural plasticity to schizophrenia

作者: Daphne Voineskos , Nigel C Rogasch , Tarek K Rajji , Paul B Fitzgerald , Zafiris J Daskalakis

DOI: 10.1177/070674371305800205

关键词:

摘要: The adaptations resulting from neural plasticity lead to changes in cognition and behaviour, which are strengthened through repeated exposure the novel environment or stimulus. Learning memory have been hypothesized occur modifications of strength circuits, particularly hippocampus cortex. Cognitive deficits, specifically executive functioning negative symptoms, may be a corollary deficits plasticity. Moreover, main excitatory inhibitory neurotransmitters associated with also extensively investigated for their role cognitive schizophrenia. Transcranial magnetic stimulation (TMS) represents some most promising approaches directly explore physiological manifestations human brain. Three TMS paradigms (use-dependent plasticity, paired associative stimulation, repetitive TMS) used evaluate neurophysiological measures healthy brain patients schizophrenia, examine brain's responses such stimulation. In consistently shown parallel molecular evidence appearing entwined this debilitating disorder. Such pathophysiology underlie learning that key symptoms disorder even mechanism involved treatment antipsychotics.

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