Prospective Randomized Multicenter Comparison of High-Frequency Oscillatory Ventilation and Conventional Ventilation in Preterm Infants of Less Than 30 Weeks With Respiratory Distress Syndrome

摘要: Background. Early use of high-frequency ventilation and exogenous surfactant is proposed as the optimal mode ventilatory support in infants with respiratory distress syndrome. In very premature infants, we tested hypothesis that versus conventional could decrease requirements improve pulmonary outcome, without altering complication rate, including severe intraventricular hemorrhage. Methods. Preterm a postmenstrual age 24 to 29 weeks, presenting syndrome were randomly assigned oscillatory (lung volume recruitment strategy) or ventilation. Results. Two hundred seventy-three enrolled. One fifty-three had 27 143 birth weight ≤1000 g. thirty-four randomized at 142 minutes life (median) receive (mean birth: 27. 6 ± 1.5 weeks; mean weight: 997 245 g); 139 145 27.5 1.4 976 219 g). High-frequency ventilation, compared was associated twofold reduction requirement for ≥2 instillations (30% vs 62%; odds ratio: .27; 95% confidence interval: .16–.44) no difference outcome. The incidence hemorrhage 24% group 14% (adjusted 1.50; .68–3.30). Conclusion. decreases requirements, does not may be an increased