Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling
作者： Ramhari Kumbhar , Sophie Vidal-Eychenié , Dimitrios-Georgios Kontopoulos , Marion Larroque , Christian Larroque
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摘要: The DNA damage response (DDR) ensures cellular adaptation to genotoxic insults. In the crowded environment of nucleus, assembly productive DDR complexes requires multiple protein modifications. How apical E1 ubiquitin activation enzyme UBA1 integrates spatially and temporally in remains elusive. Using a human cell-free system, we show that poly(ADP-ribose) polymerase 1 promotes recruitment DNA. We find association with poly(ADP-ribosyl)ated protein-DNA is necessary for phosphorylation replication A checkpoint kinase by serine/threonine ataxia-telangiectasia RAD3-related, prototypal damage. interacts directly via solvent-accessible positively charged patch conserved Animalia kingdom but not Fungi. Thus, can anchor poly(ADP-ribose)-seeded assemblies, ensuring formation functional mutated RAD3-related-signalling complexes.
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