The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice

摘要: The adult mammalian heart regenerates poorly after injury and, as a result, ischemic diseases are among the leading causes of death worldwide. recovery injured is dependent on orchestrated repair processes including inflammation, fibrosis, cardiomyocyte survival, proliferation, and contraction properties that could be modulated in patients. In this work we designed an automated high-throughput screening system for small molecules induce proliferation vitro identified molecule Chicago Sky Blue 6B (CSB). Following induced myocardial infarction, CSB treatment reduced scar size improved function mice. Mechanistically, show although initially using mouse promotes through (i) inhibition CaMKII signaling, which improves contractility; (ii) neutrophil macrophage activation, attenuates acute inflammatory response, thereby contributing to scarring. summary, potential therapeutic agent enhances cardiac by suppressing postinjury detrimental processes, with no evidence renewal.