Multiparametric MRI for the detection of local recurrence of prostate cancer in the setting of biochemical recurrence after low dose rate brachytherapy.

摘要: PURPOSE Prostate multiparametric magnetic resonance imaging (mpMRI) has utility in detecting post-radiotherapy local recurrence. We conducted a multireader study to evaluate the diagnostic performance of mpMRI for recurrence after low dose rate (LDR) brachytherapy. METHODS A total 19 patients with biochemical LDR brachytherapy underwent 3T endorectal coil T2-weighted imaging, dynamic contrast-enhanced (DCE) and diffusion-weighted (DWI) pathologic confirmation. Prospective reads by an experienced prostate radiologist were compared from 4 radiologists varying experience. Readers identified suspicious lesions rated each MRI detection parameter. MRI-detected considered true-positive ipsilateral Inferences sensitivity, specificity, positive predictive value (PPV), kappa, index specific agreement made use bootstrap resampling. RESULTS Pathologically confirmed was found 15 patients. True recurrences frequently located transition zone (46.7%) seminal vesicles (30%). On patient-based analysis, average sensitivity 88% (standard error [SE], 3.5%). For highly lesions, specificity 75% (SE, 16.5%). lesion-based PPV 62% 6.7%) all 78.7% 10.3%) lesions. The invading 88.8% (n=13). 66.6% 5.8%) 64.9% 7.3%) DCE, 70% DWI. CONCLUSION This series provides evidence that is feasible high cancer rate. Radiologists experience demonstrated moderate