Pain Related Anxiety and Pain Severity are Associated with Increased Activation of Central Arousal Circuits in Fibromylagia

摘要: Studies suggest that patients with chronic pain disorders such as fibromyalgia (FM) develop persistent symptom-specific anxiety from previous threatening stimuli, which may contribute to pain-related symptoms. The aim of this study is determine if and in FM correlates an objective, non-invasive index affective response specific contexts or stimuli (acoustic startle [ASR]). Women healthy women underwent somatic perception testing using a dolorimeter ASR testing. was measured at: 1) baseline, 2) context 3 cued threat conditions: 3) safe (no stimulation), 4) anticipation possible threat, 5) imminent aversive stimulus. To maintain anticipation, one moderately intense biceps electrical stimulus given the middle experiment. Pain severity were measured. Compared controls, demonstrated increased perception. Both groups showed increasing progressively but there no group differences. However, group, intensity correlated (r=0.52, p<0.05) anticipated (r=0.61, p<0.01) (r=0.49, p<0.05). Thus, associated enhanced responsiveness emotional arousal circuitry FM.