Protein kinase recognition sequence motifs

摘要: Protein kinases play a crucial role in the regulation of many cellular processes. They alter functions their target proteins by phosphorylating specific serine, threonine and tyrosine residues. Identification phosphorylation site sequences studies with corresponding model peptides have provided clues to how these important enzymes recognize substrate proteins. This knowledge has made it possible identify potential sites newly sequenced as well construct substrates inhibitors.