Mutations affecting development of the zebrafish retina

摘要: In a large scale screen for genetic defects in zebrafish embryogenesis we identified 49 mutations affecting development of the retina. Based on analysis living embryos as well histological sections, grouped isolated into six phenotypic categories. (1) Mutations three loci result loss wild-type laminar pattern neural (2) Defects four lead to an abnormal specification eye anlagen. Only one frequently forms this class mutants. (3) Seven predominantly affect outer retinal layers. Mutants category display cell mainly photoreceptor layer. (4) Nine cause retardation growth without any other obvious abnormalities (5) A group twelve is characterized by nonspecific degeneration. (6) Four degeneration associated with pigmentation defect. Finally, two mutations, absence ventral retina and eye-specific defect, are not classified above groups. The numerous aspects development, including: anlage, rate optic cup, establishment stratification, or differentiation neurons formation dorsoventral axis developing eye.