The Regulatory Role of the Macrophage in Normal and Neoplastic Hemopoiesis

摘要: The granulocyte-macrophage progenitor cell (colony-forming unit culture, CFU-c) can be detected by its ability to undergo clonal proliferation in semisolid medium when provided with stimulatory macromolecules operationally termed colony-stimulating factor (CSF) (3, 26, 35). A similar if not identical class of molecules also stimulates the a precursor solely committed macrophage differentiation, colony-forming unit-peritoneal (CFU-pm) (21, 23). principal cells capable elaborating CSF have been identified as monocyte (7,29) or tissue (11, 14, 29), and therefore control granulopoiesis production has postulated occur through positive feedback involving action on two hemopoietic cells, CFU-c CFU-pm 27). requirement for both CFU-pm, inability influence other growth soft agar (the B-lymphocyte murine myelomonocytic leukemic line, WEHI-3 (38)), suggest cell-type specificity this regulator ofin vitro (21).