Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas.

摘要: Colorectal cancer (CRC) forms through a series of histologic steps that are accompanied by mutations and epigenetic alterations, which is called the polyp-cancer sequence. The role such as aberrant DNA methylation, in sequence sporadic CRC particularly hereditary colon not well understood. Consequently, we assessed methylation status CDKN2A/p16, MGMT, MLH1 p14ARF adenomas arising Lynch syndrome, familial syndrome caused MSH2 mutations, to determine if “second hit” mechanism characterize polyp phase syndrome. We found methylated 53 60% 4 20% adenomas, whereas CDKN2A/p16 MGMT 6 14% versus 50 64% adenomas. Therefore, frequency pattern gene varies between implying differences molecular pathogenesis tumors. suggests might have initiation these neoplasms. © 2007 Wiley-Liss, Inc.