Pain regulation by nocistatin-targeting molecules: G protein-coupled-receptor and nocistatin-interacting protein.

摘要: Nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are neuropeptides produced from the same precursor protein. N/OFQ is involved in a broad range of central functions including pain, learning, memory, anxiety, feeding. However, NST has opposite effects on various evoked by N/OFQ. The regulation their receptors may be important for these Although binds to specific receptor, target molecule remains unclear. Some biological mediated G protein-coupled receptor. Furthermore, using high-performance affinity nanobeads, we recently identified 4-nitrophenylphosphatase domain nonneuronal SNAP25-like protein homolog 1 (NIPSNAP1) as that interacts with mouse spinal cord. inhibition N/OFQ-evoked tactile pain allodynia NIPSNAP1. This review focuses molecular mechanisms molecules receptor