Hormonal control of spermatogenesis.

摘要: The effect of estradiol benzoate (EB) testosterone propionate (TP) or pregnant mares serum gonadotropin (PMSG) administered singly in combination on spermatogenesis was studied rats. EB and TP treatment initiated the day birth. Spermatogenesis progressed EB-treated rats to a stage similar that 15-day-old untreated animals. However pachytene spermatocytes were unable complete reduction division degenerated at diakinesis. Pituitary gonadotropic hormones not necessary for progression type A spermatogonia. Spermatogonic activity inversely related duration with EB. development animals resulted markedly increased testicular weight when compared treated only. Thus primary requires testosterone. proceeds up Step 7 spermiogenesis through influence TP; addition PMSG completes spermiogenesis. Follicle-stimulating hormone is required completion It suggested dose gonadotropins critical importance quantitative initiation maintenance although exact hormonal requirements normal are unclear.