Initial FDG uptake in patients with adenocarcinomas of the esophagogastric junction (AEG): Is it correlated to tumor localization and to patients' survival?

摘要: 1626 Objectives: Comparison of F-18-FDG uptake in AEG according to their localization and evaluation the initial for prediction patient survival. Methods: 154 patients (pts) with I-III (T3 N0/+ M0; mean age 57 + 6.5 years) underwent whole body PET scan prior neoadjuvant chemotherapy using an ECAT EXACT scanner. 72 pts were classified Siewert et al [Br.J.Surg 85: 1457-9] as I, 52 II 30 III. Scan protocol comprised a 20 min emission over tumor 40 after injection approximately 370 MBq F-18-FDG. For attenuation correction Ge-68-transmission was performed. Mean standardized values (SUV) lesions calculated by placing circular ROI (diameter 1.5 cm) transversal slice maximum activity tumor. assessment prognostic significance Kaplan-Meier analysis Results: Across all groups SUVmean 8.8 5.7. The I 8.5 4.5, 8.4 5.2 III 10.5 8.4. difference FDG-uptake depending on not significant (AEG vs. p=0.97, p=0.23 p=0.24). did prove be factor survival (p=0.34). Notably, separate three different group’s only (p=0.028). Cox-Regression revealed that across differ significantly. However showed tendency shorter (p=0.11). Conclusions: There is no adenocarcinomas esophagogastric junction (I-III) localization. Overall, SUV Patients show