The lowest X4 Geno2Pheno false‐positive rate is associated with greater CD4 depletion in HIV‐1 infected patients

摘要: Through this study we evaluated whether the HIV-1 tropism determined by genotypic analysis correlates with markers, such as CD4 cell count and plasma HIV-RNA. The was performed on 1221 B-subtype infected patients an available V3 sequence (all maraviroc naive). Of them, 532 were antiretroviral therapy (ART) naive 689 ART experienced. Tropism determination using geno2pheno (co-receptor) algorithm set at a false-positive rate (FPR) of 10% 2%. Potential associations FPR viraemia evaluated. Association mutations genotypic-determined also according to different ranges. About 26% (either or experienced) X4-tropic viruses (using classical cut-off). However, significantly lower proportion ART-naive had £ 2% in comparison ART-experienced (4.9% vs. 12.6%, respectively, p <0.001). risk advanced infection (with 200 cells/mm 3 ) greater X4-infected patients, either (OR (95% CI)), 4.2 (1.8‐9.2); 0.0006) (2.3 (1.4‐3.6); 0.0003), (but not 10%). This finding confirmed multivariable logistic analysis. No relationship found between £2%. Some X4-related associated £2% (ART-naive S11R, Y21V, G24K G24R, £0.001; Y7K, H13Y, £0.002). In conclusion, these findings show that within context genotypically-assessed CXCR4 tropism, defines (far better than 10%-FPR) viral population low rank, potentially cytopathic effect, more disease.