Forty-seven years experience with gold therapy in 1,019 rheumatoid arthritis patients.

摘要: T HIS REVIEW was derived from a survey of 7,750 patient records 1933 to 1979. Much the data concerns special group 1,019 patients with rheumatoid arthritis (RA) treated gold salts, many whom have been referred in previous publications.’ ” The classical or dehnite RA according American Rheumatism Association criteria’ were disodium (thiomalate-S) aurate (I) (Myochrysine Merck Sharp & Dohme, West Point, Pa) and followed prospectively. Of this 3 I7 men 702 women (median ages 46 47 years, respectively). Their age at onset is detailed Table I. decision start Myochrysine based on progression 01 active unresponsive therapy aspirin. later phenylbutazone indomcthacin. then by newer nonsteroidal antiinflammatory drugs agents. given initially as IO-mg test dose, :I 25-rng dose one week later. If no adverse reaction occurred, weekly injections 40 mg intramuscularly (IM) administered until least 800 had given. Then maintenance IM ever!’ two four weeks. same dosage schedule throughout course. Efficacy monitored ;I moditication similar assessment functional class radiographic staging after criteria Steinbrocker et al.” Considering that some these predated criteria. all reviewed for sake consistency. None ToxIcit! ML{\ monItored using clc)‘rc mouitilr ing \\btem \lmil:lr recentI\ de\crlbcti Skin toxicit! \\:I\ :in! event ~~thcrMi\~ unc~ plained skin ra\h. dermatitis. ;ind/or ItchIn? Buccal irritation W;I~ ;In> Llphthous-like u/ccr\ II> mouth. :tn\ burning sensaticjrt bucc,li mcmbranc\. Ren;tl consisted prc“cncc hcmaturl;i. red cell and/cx an\ h!alinc GlSl\. ;L\ hell ;I\ t hc prcscnce protein n 1 urine ;i> mea\urcd b! x~lvcyl-sulphonic acid IC\I arid/c>>> dipstick 1.o~ platelet count v.;I~ a~cs~d