Interaction between invariant NKT cells and myeloid-derived suppressor cells in cancer patients: evidence and therapeutic opportunities.

摘要: Despite advances in therapeutic strategies, the ability of cancer cells to evade destruction remains a significant obstacle development effective anticancer treatment. In recent years subset immune cells, myeloid-derived suppressor (MDSCs), has been shown play key role evasion patient's system by tumor cells. A number different types are associated with increased numbers circulating MDSCs patients, suppressing response and permitting continued cell proliferation. Invariant NKT (iNKT) have recently defined as unique that able act link between innate adaptive arms system. iNKT carry out surveillance control proliferation malignant Recently, we presented evidence interact decrease melanoma patients. This review discusses for progression implication could be developed potent strategy.