Impact of HIV-1 Infection and Antiretroviral Therapy on Bone Homeostasis and Mineral Density in Vertically Infected Patients

摘要: Daily assumption of antiretroviral drugs and HIV-related immune activation lead to important side effects, which are particularly evident in vertically infected patients. Bone homeostasis impairment reduction bone mineral density (BMD) is one the most effects. Primary aim this study assess prevalence alterations a group patients; secondary analyze relationship between anthropometric data, severity HIV infection, therapy. We studied 67 patients with transmitted HIV-1 (aged 6-31 years), followed by Pediatric Infectious Disease Unit University Hospital Padua, Italy. analyzed turnover markers (P1NP CTx) we performed lumbar spine femoral dual energy X-ray absorption densitometry (DXA). Personal data information on HIV-infection therapy were collected for all found that BMD values recorded DXA showed significant correlation age, race, BMI, physical activity, duration. P1NP was increased 43% patients, while CTX 61% them. alteration related duration, ever use protease inhibitors nucleotide reverse transcriptase inhibitors. be correlated only age. In conclusion, our confirms wide percentage show reduced impaired homeostasis. Strict monitoring needed order early identify treat these conditions.