Promotion of B Cell Immune Responses via an Alum-Induced Myeloid Cell Population

摘要: Exposure of naive B cells to the cytokine interleukin-4 (IL-4) and/or antigen leads a state “priming,” in which subsequent aggregation major histocompatibility complex class II molecules induces mobilization calcium ions and cell proliferation. However, it is not clear how critical this priming for immune responses or normally induced vivo. Injection mice with commonly used adjuvant alum led splenic accumulation spleen previously unknown population IL-4–producing, Gr1+ cells. These IL-4 were both required vivo expansion antigen-specific cells, as well optimal production antibody. studies reveal key role accessory myeloid generation humoral responses.