Left ventricular extracellular volume fraction and atrioventricular interaction in hypertension.

摘要: Left atrial enlargement (LAE) predicts cardiovascular morbidity and mortality. Impaired LA function also confers poor prognosis. This study aimed to determine whether left ventricular (LV) interstitial fibrosis is associated with LAE impairment in systemic hypertension. Following informed written consent, a prospective observational of 86 hypertensive patients (49 ± 15 years, 53% male, office SBP 168 30 mmHg, DBP 97 4 mmHg) 20 normotensive controls (48 13 55% 130 80 11 at 1.5-T magnetic resonance was conducted. Extracellular volume fraction (ECV) calculated by T1-mapping. (LAV) measured biplane area-length method. reservoir, conduit pump were the phasic volumetric Indexed LAV correlated indexed LV mass (R = 0.376, p < 0.0001) ECV 0.359, 0.001). However, strongest significant predictor multivariate regression analysis (odds ratio [95th confidence interval] 1.24 [1.04–1.48], 0.017). myocardial reductions reservoir -0.437, -0.316, 0.003) but not -0.167, 0.125) function. Multiple linear regression, correcting for age, gender, BMI, BP diabetes, showed an independent decrease 3.5% total emptying each 10 ml/m2 increase (standard β coefficient -3.54, 0.002). extracellular expansion impaired Future studies should identify if targeting diffuse beneficial reverse remodelling structural functional pathological abnormalities • are markers adverse prognosis hypertension their pathophysiology poorly understood. function. may play central role atrioventricular interaction