Mechanistic Aspects of Green Tea as a Cancer Preventive: Effect of Components on Human Stomach Cancer Cell Lines
作者： Sachiko Okabe , Yumiko Ochiai , Miwa Aida , Keunchil Park , Seong-Jin Kim
DOI: 10.1111/J.1349-7006.1999.TB00808.X
关键词:
摘要: It is now well accepted that (-)-epigallocatechin gallate (EGCG) inhibits carcinogenesis in the digestive tract rodents. To understand mechanisms of anticarcinogenesis, we first studied growth inhibition by EGCG human stomach cancer cell lines established at Seoul National University (SNU lines). Inhibition [3H]thymidine incorporation into eight SNU was examined, relation to transforming factor-beta (TGF-beta) responsiveness. Various tea polyphenols derived from green and black induced apoptosis line KATO III, tumor necrosis factor-alpha (TNF-alpha) release cells, order (-)-epicatechin (ECG), EGCG, (EGC), teaflavins (TF) (EC). In addition, demonstrated inhibited TNF-alpha gene expression III as okadaic acid-induced AP-1 NF-kappa B activation. The inhibitory potencies for binding DNA were different between cells mouse fibroblast BALB/3T3. Thus, other may interact with various transcription factors, addition B, nuclei resulting release.
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