Are dendritic cells the most appropriate therapeutic vaccine for patients with ovarian cancer

摘要: New treatments are urgently needed in patients with ovarian cancer (OC), as diagnosis is delayed many instances, resulting 85% recurrence of the disease following surgery and standard chemotherapy. OC considered to be an immunological type cancer, despite its limited response current immunotherapy options, including vaccination. Thus, additional interventions may improve their efficacy. Dendritic cells (DCs) most widely used cellular vaccination therapy due crucial role initiation development immune response. There viable options for DC-vaccination a favorable toxicity profile, but specific alternatives should consider therapeutic effectiveness treatment. In this respect, B-cells macrophages provide possibilities that explored immunotherapy. Here we state-of-the-art strategies treatment evaluate potential future improvements.