摘要: Serum leptin levels are increased in obesity proportion to the amount of body fat. Gender and fat distribution into subcutanous or visceral adipose tissue depots contribute greater serum women than men equivalent mass. circulates plasma association with a binding protein comprised extracellular domain receptor. The postprandial surge insulin glucose stimulate synthesis diurnal pattern leptin. Hexosamine biosynthesis adipocyte size adipocytes obese subjects. Leptin resistance describes inability reduce food intake decrease weight subjects elevated levels. Selective results some systems remaining responsive obesity. contributes related hypertension may other metabolic complications
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