Exogenous Glutathione Attenuates Stunning Following Intermittent Hypoxia in Isolated Rat Hearts
作者： K. S. Seiler , J. P. Kehrer , J. W. Starnes
DOI: 10.3109/10715769609088007
关键词:
摘要: An isolated rat heart model of intermittent hypoxia was used to investigate the impact exogenous supplementation glutathione and two thiol delivery vehicles on functional recovery during reoxygenation whether efficacy dependent enhanced intracellular concentration. Hearts from F344 rats were perfused in Langendorff mode exposed three, 5 minute bouts global, substrate free, normothermic separated by periods. Changes coronary flow, rate, systolic diastolic pressure, rate pressure product evaluated throughout control hearts compared with which one following provided hypoxic periods: reduced (GSH, 1 or 10 mM), mM GSH mono-ethyl ester (GSHMEE), L-2-oxothiozolidine-4-carboxylate (OZT). After three periods plus reoxygenation, - 60% pre-hypoxic values. Exposing GSH, GSHMEE, O...
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