Does Folic Acid Supplementation Prevent or Promote Colorectal Cancer? Results from Model-Based Predictions

摘要: Folate is essential for nucleotide synthesis, DNA replication, and methyl group supply. Low-folate status has been associated with increased risks of several cancer types, suggesting a chemopreventive role folate. However, recent findings on giving folic acid to patients history colorectal polyps raise concerns about the efficacy safety folate supplementation long-term health effects fortification. Results suggest that undetected precursor lesions may progress under supplementation, consistent in synthesis cell proliferation. To better understand possible trade-offs between protective due decreased mutation rates possibly concomitant detrimental proliferation acid, we used biologically based mathematical model carcinogenesis. We predict changes risk timing treatment start potential effect rates. Changes response are likely complex function start, duration, mutations Predicted incidence mostly higher than without unless initiated early life (before age 20 years). extent which this predicts reality, it indicates when starting late small, yet detrimental. Experimental studies needed provide direct evidence dual validate improve predictions.